Rescale Wins DOE Genesis Mission Funding for Agentic AI Initiative
Rescale, a digital engineering platform built for the AI era, has secured funding through the Genesis Mission, a U.S. Department of Energy (DOE) initiative designed to create the world's most advanced integrated science discovery platform. As part of the Agentic HPC Pipeline Initiative (AHPI), Rescale will collaborate with Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, and Oak Ridge National Laboratory to leverage agentic AI for accelerating industry adoption of cutting-edge simulation software developed by U.S. national laboratories.
Created through an executive order in November 2025, the Genesis Mission brings together the DOE's network of 17 national laboratories and approximately 40,000 scientists and engineers to speed advances in energy, scientific research, and national security. The initiative combines artificial intelligence, high-performance computing, quantum technologies, and advanced scientific instruments into a unified discovery platform. DOE leaders have likened its scope and long-term impact to landmark national efforts such as the Manhattan Project and the Apollo program, with the goal of doubling U.S. scientific research productivity over the next decade.
Earlier this year, the DOE introduced the first major funding opportunity under the Genesis Mission, committing $293 million to projects addressing national priorities in advanced manufacturing, biotechnology, nuclear energy, critical materials, and quantum information science. The competition attracted more than 8,000 applications, the largest response ever received for a single DOE funding program and nearly three times the department's previous record. This marks the first phase of what is expected to become a multi-year investment program.
By earning Phase I funding, AHPI—and Rescale as a consortium member—was selected from an exceptionally competitive applicant pool. The initiative focuses on overcoming a longstanding challenge in federally funded research: although U.S. national laboratories have developed world-class engineering simulation software over several decades, widespread industrial adoption has remained limited because operating these sophisticated tools requires specialized expertise and computing infrastructure.
Rescale is the only commercial technology company participating in the AHPI consortium. Working alongside the three national laboratories, the company will integrate agentic AI capabilities into the WarpX, LiDO, and Adamantine simulation codes, originally developed by Lawrence Berkeley, Lawrence Livermore, and Oak Ridge National Laboratories, respectively. Through the Rescale platform, AI agents will assist engineers with selecting the appropriate simulation code, configuring input parameters, monitoring simulation progress, and interpreting results. The initiative aims to reduce the expertise and time needed to perform these simulations by more than five times, enabling U.S. manufacturers to independently access tools that previously required direct laboratory support.
"Lawrence Berkeley National Laboratory has spent decades advancing computational science, and an important part of our mission is ensuring those innovations benefit organizations beyond the laboratory," said Peter Nugent, Division Deputy for Science in the Applied Mathematics and Computational Research Division at Lawrence Berkeley National Laboratory and principal investigator for AHPI. "By working together with Lawrence Livermore and Oak Ridge through AHPI, we can make these powerful technologies more accessible to American manufacturers."
Joris Poort, CEO of Rescale, said the Genesis Mission underscores the importance of putting advanced AI capabilities into the hands of leading research and development teams to maximize the value of both public and private investment. He noted that Rescale's experience working with government agencies and industry over the past 15 years positions the company to help transition advanced AI-driven simulation technologies from national laboratories into practical use by U.S. manufacturers.
The award also strengthens Rescale's ongoing collaboration with Oak Ridge National Laboratory's Manufacturing Demonstration Facility, which already provides manufacturers with access to simulation tools developed at ORNL. AHPI seeks to address a common limitation in laboratory-industry partnerships: once a DOE-funded collaboration concludes, companies retain the knowledge gained during the project but often lose access to the specialized software and workflows that enabled those discoveries. By preserving AI-powered workflows, surrogate models, and configured simulation environments on the Rescale platform, AHPI will allow researchers and industry partners to continue collaborating long after individual DOE-funded projects have ended.
Rescale's inclusion in AHPI reflects growing recognition that making federally developed scientific software more accessible to commercial industry is essential for accelerating innovation and strengthening U.S. technological competitiveness.
Created through an executive order in November 2025, the Genesis Mission brings together the DOE's network of 17 national laboratories and approximately 40,000 scientists and engineers to speed advances in energy, scientific research, and national security. The initiative combines artificial intelligence, high-performance computing, quantum technologies, and advanced scientific instruments into a unified discovery platform. DOE leaders have likened its scope and long-term impact to landmark national efforts such as the Manhattan Project and the Apollo program, with the goal of doubling U.S. scientific research productivity over the next decade.
Earlier this year, the DOE introduced the first major funding opportunity under the Genesis Mission, committing $293 million to projects addressing national priorities in advanced manufacturing, biotechnology, nuclear energy, critical materials, and quantum information science. The competition attracted more than 8,000 applications, the largest response ever received for a single DOE funding program and nearly three times the department's previous record. This marks the first phase of what is expected to become a multi-year investment program.
By earning Phase I funding, AHPI—and Rescale as a consortium member—was selected from an exceptionally competitive applicant pool. The initiative focuses on overcoming a longstanding challenge in federally funded research: although U.S. national laboratories have developed world-class engineering simulation software over several decades, widespread industrial adoption has remained limited because operating these sophisticated tools requires specialized expertise and computing infrastructure.
Rescale is the only commercial technology company participating in the AHPI consortium. Working alongside the three national laboratories, the company will integrate agentic AI capabilities into the WarpX, LiDO, and Adamantine simulation codes, originally developed by Lawrence Berkeley, Lawrence Livermore, and Oak Ridge National Laboratories, respectively. Through the Rescale platform, AI agents will assist engineers with selecting the appropriate simulation code, configuring input parameters, monitoring simulation progress, and interpreting results. The initiative aims to reduce the expertise and time needed to perform these simulations by more than five times, enabling U.S. manufacturers to independently access tools that previously required direct laboratory support.
"Lawrence Berkeley National Laboratory has spent decades advancing computational science, and an important part of our mission is ensuring those innovations benefit organizations beyond the laboratory," said Peter Nugent, Division Deputy for Science in the Applied Mathematics and Computational Research Division at Lawrence Berkeley National Laboratory and principal investigator for AHPI. "By working together with Lawrence Livermore and Oak Ridge through AHPI, we can make these powerful technologies more accessible to American manufacturers."
Joris Poort, CEO of Rescale, said the Genesis Mission underscores the importance of putting advanced AI capabilities into the hands of leading research and development teams to maximize the value of both public and private investment. He noted that Rescale's experience working with government agencies and industry over the past 15 years positions the company to help transition advanced AI-driven simulation technologies from national laboratories into practical use by U.S. manufacturers.
The award also strengthens Rescale's ongoing collaboration with Oak Ridge National Laboratory's Manufacturing Demonstration Facility, which already provides manufacturers with access to simulation tools developed at ORNL. AHPI seeks to address a common limitation in laboratory-industry partnerships: once a DOE-funded collaboration concludes, companies retain the knowledge gained during the project but often lose access to the specialized software and workflows that enabled those discoveries. By preserving AI-powered workflows, surrogate models, and configured simulation environments on the Rescale platform, AHPI will allow researchers and industry partners to continue collaborating long after individual DOE-funded projects have ended.
Rescale's inclusion in AHPI reflects growing recognition that making federally developed scientific software more accessible to commercial industry is essential for accelerating innovation and strengthening U.S. technological competitiveness.
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